منابع مشابه
Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors
Botulinum neurotoxins (BoNTs) include seven bacterial toxins (BoNT/A-G) that target presynaptic terminals and act as proteases cleaving proteins required for synaptic vesicle exocytosis. Here we identified synaptic vesicle protein SV2 as the protein receptor for BoNT/D. BoNT/D enters cultured hippocampal neurons via synaptic vesicle recycling and can bind SV2 in brain detergent extracts. BoNT/D...
متن کاملSynapsin Isoforms and Synaptic Vesicle Trafficking
Synapsins were the first presynaptic proteins identified and have served as the flagship of the presynaptic protein field. Here we review recent studies demonstrating that different members of the synapsin family play different roles at presynaptic terminals employing different types of synaptic vesicles. The structural underpinnings for these functions are just beginning to be understood and s...
متن کاملSynaptic Vesicle Protein 2 ( SV 2 ) does not hydrolyze ATP
Synaptic vesicle protein 2 (SV2) is a transporter-like protein specifically expressed in endocrine cells and neurons, where it is localized to vesicles that undergo regulated secretion and plays an essential role in regulating neurotransmitter release. SV2 binds adenine nucleotides including ATP. Analysis of ATP transport revealed that SV2 is not an ATP transporter, nor does it affect ATP trans...
متن کاملThe synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
Interactions between growing axons and synaptic basal lamina components direct the formation of neuromuscular junctions during nerve regeneration. Isoforms of laminin containing alpha5 or beta2 chains are potential basal lamina ligands for these interactions. The nerve terminal receptors are unknown. Here we show that SV2, a synaptic vesicle transmembrane proteoglycan, is complexed with a 900-k...
متن کاملVesicle-associated membrane protein (VAMP)/synaptobrevin-2 protein mutants functionality test in synaptic vesicle fusion
Praggastis, Sophia, "Vesicle-associated membrane protein (VAMP)/synaptobrevin-2 protein mutants functionality test in synaptic vesicle fusion" (2014). Undergraduate Honors Theses. Paper 181.
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Cancer Prevention
سال: 2012
ISSN: 1513-7368
DOI: 10.7314/apjcp.2012.13.10.5063